Thorne PharmaGABA-250 60 VCaps
Gamma-aminobutyric acid (GABA) is a major neurotransmitter widely distributed throughout the central nervous system. Because too much excitation can lead to irritability, restlessness, sleeplessness, and spasmodic movements, this excitation needs to be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – can provide this inhibition, acting like a "brake" during times of runaway stress. In addition, studies also indicate GABA can promote relaxation and enhance sleep. It is thought that either low GABA levels or decreased GABA function in the brain may have an adverse impact on neurological health.
Stress is a normal part of life. Job pressures, family contention, financial insecurity, traffic, and time management are just a few of the stressors we are faced with on a daily basis. For some people, the effects can be overwhelming, leading to feelings of nervousness. Managing stress can exert beneficial effects on the cardiovascular, immune, and neuroendocrine systems.
GABA regulates nervousness by calming excitatory neurotransmitter activity
Increased GABA levels improve mental focus and relaxation, without drowsiness
In at least one study, natural PharmaGABA decreased signs of stress; synthetic GABA did not
The natural GABA in Thorne's PharmaGABA-250 is produced via a fermentation process that utilizes Lactobacillus hilgardii, the bacteria used to ferment vegetables in the preparation of the traditional Korean cabbage dish known as kimchi. Clinical studies show this natural form of GABA can increase the production of alpha-waves in the brain, creating a profound sense of physical relaxation while maintaining mental focus. In contrast, the stress-related beta-waves in the brain are decreased. In addition to changes in brain waves, natural PharmaGABA has been shown to produce relaxation, as evidenced by reduced pupil diameter, heart rate, and two natural markers of stress – salivary cortisol and chromogranin A. In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, synthetic GABA did not demonstrate these positive effects.
In addition to changes in brain waves, PharmaGABA has been shown to produce relaxation as evidenced by reduced pupil diameter, heart rate, and markers of stress - salivary cortisol and chromogranin A. In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, the synthetic GABA did not demonstrate these effects.
A study on healthy male athletes using PharmaGABA added to a beverage showed a reduction in stress markers during and after exercise. Additional clinical studies with PharmaGABA yield further evidence of its anti-stress activity. Secretory IgA (sIgA) is am important antibody in saliva that helps support immune function. Typically, during times of stress salivary sIgA levels drop. In one study, subjects with acrophobia (fear of heights) traversed a long walk suspension bridge that spanned a 150-foot high canyon. Salivary sIgA levels decreased when subjects were given a placebo; however, when they were given PharmaGABA, salivary sIgA levels were maintained half-way across the bridge and actually increased upon completion of the crossing.
Thorne PharmaGABA-250 60 VCaps